The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency

Introduction. Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity atherosclerosis. The results studies association various polymorphisms vitamin receptor ( VDR ) gene with risk CHD are contradictory, which necessitates study genetic variants characteristics clinical course in Russian population. objective was to determine distribution genotypes TaqI , BsmI ApaI polymorphic level sufficiency patients varying CHD, residents St. Petersburg. Methods materials. included 407 318 without signs comparable age (p>0.05). All underwent angiography. Typing performed by polymerase chain reaction subsequent restriction analysis. Determination 25(OH)D blood serum carried out enzyme immunoassay. Results. detected 82 % patients, content lower who had 2 or more myocardial infarctions (MI) than those one MI (p=0.03). is associated a 3.6-fold increased multivessel (p=0.01). presence aa genotype allele (ApaI), bb b atherosclerotic lesions arteries. Conclusion. typical for polymorphism), polymorphism) polymorphism not CHD.